Asking Too Much of Epidemiologic Studies

β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

The islet in type 2 diabetes (T2DM) is characterized by a deficit in β-cells, increased β-cell apoptosis, and extracellular amyloid deposits derived from islet amyloid polypeptide (IAPP). In the absence of longitudinal studies, it is unknown if the low β-cell mass in T2DM precedes diabetes onset (is a risk factor for diabetes) or develops as a consequence of the disease process. Although insuli...

Teenage Blood Donors: Are We Asking Too Little and Taking Too Much?

Young blood donors contribute substantially to the US blood supply, yet these are the donors at greatest risk of immediate reactions and other adverse health effects related to their blood donations. Sixteen and 17-year-old adolescents constitute only 2.8% of the US population, but they contribute an estimated 10% of the blood supply, with more than 1 million donations per year.1 Mass recruitme...

Respondent burden in clinical research: when are we asking too much of subjects?

How much is too much?

An investigation of the effect of the number of choice sets, starting point and the choice of bid vectors in choice experiments

Asking too much: autonomy and responsibility at the end of life.